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This model proposes that mGSH depletion due to its covalent binding to NAPQI acts as a first-hit, which is followed by a burst of mitochondrial ROS production that activates a second hit involving mitogen-activated protein kinases (MAPKs) that in turn amplifies the wave of mitochondrial ROS generation (Lemasters, 1998)

Conversely, miR-10b-5p enhances the secretion of chemokines CCL2 and CXCL8 by targeting BDNF in granulosa cells, thereby supporting ovulation (Yuan et al., 2023)

Causal criteria and counterfactuals

Athletes, active professionals, and performance-focused adults are paying closer attention to how they restore, reset, and stay consistent over time

Update 27 (4), 771796