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Its derivative, 4-octyl itaconate (4-OI), activates the Nrf2 pathway by alkylating Keap1, thereby inducing antioxidant enzymes such as HO-1 and NQO1 to scavenge reactive oxygen species and alleviate oxidative stress in SLE

Mahmoudi-Lamouki et al., 2023)

Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: role of Bnip3 and Pdk1

These molecules jam the intracellular signalling cascade, so even though insulin docks at its receptor, the message never travels downstream

These women were randomly divided into two groups: one group (n = 17) received ALA (400 mg/day) in the form of hard vaginal tablets and the control group (n = 15) received the placebo