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Additionally, the interindividual variability in gut microbiota composition significantly influences polyphenol biotransformation into bioactive metabolites, complicating the prediction of therapeutic outcomes and impeding the standardization of treatments (Cardona et al

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Conversely, unstimulated microglia appear to bolster the expression of TJ proteins within co-cultured endothelial cells, demonstrating a protective or restorative role of microglia in BBB integrity (Mehrabadi et al., 2017)