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Trx is a widely distributed small dithiol protein that contains 104 amino acids, including one disulfide bridge, two SH groups, and a conserved active site (Trp-Cys-Gly-Pro-Cys) [119]

While little is known about the precise dynamics of the reduction, a weakly positive individual may become negative within weeks of strict adherence to GFD

26 , 30513060.e3054 (2019)

Mitochondria-targeted therapies, including antioxidants [such as, coenzyme Q10, N-acetylcysteine (NAC) and -lipoic acid] and mitochondrial nutritional supplements, have emerged as promising alternatives aimed at mitigating oxidative stress and restoring mitochondrial function