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Gu C, Zhang Q, Li Y, Li R, Feng J, Chen W, Ahmed W, Soufiany I, Huang S, Long J, Chen L (2022) The PI3K/AKT pathway-the potential key mechanisms of traditional chinese medicine for stroke

4.3 Heme oxygenase-1 (HO-1, also known as HSP32) Increased HO-1 levels may cause an excessive accumulation of iron and carbon monoxide, resulting in oxidative stress and cellular damage