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Because we previously reported that old C57BL/6J mice and older adults share many age-associated abnormalities [14,22,64], these mice were an ideal to conduct our investigation of cognitive decline and brain abnormalities in aging

10.3389/fnins.2018.00466 2 AbeK.PanL

Recently, a plethora of studies have shown that ferroptosis also plays a critical role in a variety of pathophysiological processes such as ischemic organ injury, stroke, cardiac myopathy, and neurodegenerative diseases

Both reactions are fundamental to cellular energy metabolism

177 Hormones like estrogen and relaxin can alter the synthesis and degradation of collagen, affecting its density, cross-linking, and alignment