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Early research described it as relatively selective for GH release compared with some older secretagogues (Raun et al., 1998)

At the local level, the asthma-related changes include disturbances in the balance of Th1/Th2 pro- and anti-inflammatory cytokines, an increased cellular influx into the bronchi, chronic oxidative stress, and airway hyperreactivity

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These models should integrate key features such as vascular remodeling, BBB integrity, and neuronal-vascular cell interactions to accurately simulate neurovascular dynamics