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4.2 Potential of other neurotrophic factors Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor with a wide range of biological actions that positively affect the viability, proliferative activity, and migratory ability of cells in the nervous system (Revishchin et al., 2022)

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Conclusion It is no secret that testosterone levels play a key role in several bodily processes

Under the stimulation of high mechanical stress, activation of the PIEZO1 protein leads to a decrease in the intracellular GSH level of chondrocytes, a reduction in the function and expression of GPX4, and a significant increase in the intracellular calcium ion concentration, ultimately inducing ferroptosis of chondrocytes