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This misunderstands basic receptor biology

Once breakdown starts, a protein called intrinsic factor, released by parietal cells in the stomach, binds to vitamin B12 in the duodenum (small intestine) and forms a B12-intrinsic factor complex that allows B12 to be absorbed in the terminal portion of the small intestine

Some people notice improved energy or less tingling within days, but meaningful relief of numbness or burning from neuropathy can take several weeks to months

**Vit B -6 sources include chicken, salmon, tuna, walnut, peanut, chickpeas, maize, whole grain cereals, green leafy vegetables, bananas, potatoes etc

Therefore, while B12 may be beneficial on its own for anxiety, taking a supplement with all eight B vitamins (or one containing just those three vitamins) may produce more significant benefits