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National Health Insurance (NHI) Drug Price (Scheduled to be listed on December 20): LEQEMBI Intravenous Infusion 200mg 45,777 JPY per vial LEQEMBI Intravenous Infusion 500mg 114,443 JPY per vial Packaging: LEQEMBI Intravenous Infusion 200mg 2mL per vial LEQEMBI Intravenous Infusion 500mg 5mL per vial Warnings and Contraindications 1.Warning 1.1Prior to initiating administration of this drug, sufficient information should be provided to patients and their families/caregivers about the occurrence rate of ARIA due to this drug, the risk of ARIA, tests necessary for risk management, and measures to be taken when ARIA occurs

GPx4 is expressed in two isoforms

Structure of the allosteric regulatory enzyme of purine biosynthesis

doi: 10.1016/j.aquaculture.2019.734781 69 ZhouY

However, due to its strong oxidizing properties, prolonged exposure to high doses of ozone can cause burns and even carcinogenic effects when in contact with skin and mucous membranes (30)