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Considering the estrogen receptor, hypermethylation of the estrogen receptor 1 ( ESR1 ) promoter by mechanisms involving zinc finger E-box-binding homeobox 1 (ZEB1) and interleukin-1 (IL-1) reduces its transcription and, therefore, ER protein expression which confers resistance to tamoxifen treatments [149,150,151]

[107] emphasized the need to combine the minimal criteria to identify MSCs as suggested by the International Society for Cell Therapy [108] and the recommendations of the International Society for Extracellular Vesicles, which were updated in 2018 [109]