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To mechanistically dissect gut-brain crosstalk in this framework, we propose: (i) gnotobiotic mouse models comparing stroke outcomes in microbiota-depleted versus Akkermansia-reconstituted cohorts to establish causality

In order to explore whether the applied magnetic force causes only the accumulation of MNPs near the cells or whether it can also influence the endocytosis and intracellular pathways, we carried out the transfection experiments with and without the influence of magnetic-field