The National Institutes of Health notes: "Methylmalonic acid is the most specific marker of B12 deficiency at the tissue level and should be measured when serum B12 is between 200 and 400 pg/mL" [9]
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AsCy5 5-(2-fluoro-5-((1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl)phenyl)isoxazole-3-carboxylic acid - 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzyl)thiazolidine-2,4-dione 67.90% inhibition at 0.02 mg/ml 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione a potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties - 5-(4-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxyphenoxy)benzyl)thiazolidine-2,4-dione 94.27% inhibition at 0.02 mg/ml 5-acetylamino-2-(2,5-dimethyl-1H-pyrrol-1-yl) benzoic acid 5-chloro-2-[methyl(methylidene)-lambda4-sulfanyl]-6-[(naphthalen-2-yl)oxy]-1H-benzimidazole 65% inhibition at 0.2 mM 5-chloro-N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-1-methyl-2-(methylthio)-1H-benz-imidazole-6-carboxamide mixed-type inhibition, complete inhibition at 0.2 mM 5-methoxy-4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-2-(2-methylbut-3-en-2-yl)phenyl acetate - a semisynthetic licochalcone A derivative 6,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one - 6,8-dibenzyl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.013 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6,8-difluoro-4-methyl-2-oxo-2H-1-benzopyran-7-yl ethenesulfonate - 6-((1-(benzylsulfonyl)piperidin-4-yl)amino)-3-(carboxymethoxy)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid - - 6-((2-benzyl-1-benzothien-3-yl)methyl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0032 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM 6-((E)-1,2-diphenylvinyl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0097 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-(1-benzothien-2-ylmethyl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.006 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-(1-benzothien-3-yl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0077 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-(1-benzothien-3-ylmethyl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.06 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-(10-bromo-9-anthryl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0025 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR at 0.57 mM 6-(4-((2-benzyl-1-benzothiophen-3-yl)methyl)phenyl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0011 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM 6-(4-((2-benzyl-1-benzothiophen-3-yl)methyl)phenyl)-4-oxo-8-phenyl-4H-chromene-3-carbaldehyde 50% inhibition at 0.001 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR at 0.52 mM 6-(4-(3-(3-(benzyloxy)-2-(methoxycarbonyl)phenoxy)propyl)piperazin-1-yl)-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid - IC50 of 45.2 mg/ml 6-(4-benzylpiperazin-1-yl)-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid - 62.3% inhibition at 0.02 mg/ml 6-(9-anthryl)-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0071 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-amino-1-(4-fluorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid - 12.4% inhibition at 0.02 mg/ml 6-benzyl-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid - 87.5% inhibition at 0.02 mg/ml 6-benzyl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.036 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-biphenyl-4-yl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0043 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-biphenyl-4-yl-4-oxo-8-phenyl-4H-chromene-3-carbaldehyde 50% inhibition at 0.002 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases, 50% inhibition of isoform LAR above 1 mM 6-bromo-3-carboxymethoxy-benzo(b)-thiophene-2-carboxylic acid - - 6-bromo-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.020 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-chloro-7-(2,3-dihydro-1H-inden-1-ylamino)quinoline-5,8-dione - 6-chloro-7-[(2-morpholin-4-ylethyl)amino]quinoline-5,8-dione - 6-dibenzo(b,d)thien-1-yl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.0076 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-dibenzo(b,d)thien-4-yl-4-oxo-4H-chromene-3-carbaldehyde 50% inhibition at 0.011 mM, irreversible, selective for isoform PTP1B over other human protein tyrosine phosphatases 6-fluoro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid 6-hydroxy-2-(4-hydroxybenzyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one 6-hydroxy-3-[1-[4-(naphthalen-1-ylamino)-4-oxobutyl]-1H-1,2,3-triazol-4-yl]-2-phenyl-1-benzofuran-5-carboxylic acid - - 6-hydroxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylate - 80% residual activity at 0.1 mM 6-hydroxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid 6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid - IC50 of more than 20 mg/ml 6-oxo-6H-cyclohepta[b]furan-5,7-dicarboxylic acid - 7-(2-((1H-imidazol-2-yl)thio)ethoxy)-2-phenyl-4H-chromen-4-one - 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one the inhibitor is significantly selective for enzyme protein tyrosine phosphatase 1B (PTP1B) versus other phosphatases, i.e
Thyroid Dysfunction Uncontrolled thyroid disorders may heighten susceptibility to side effects, especially those affecting metabolism or cardiovascular function
