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During the preliminary pre-experiment stage, we set up a series of concentration gradients for preliminary exploration and found that the three concentrations of CPI2 (0.5, 1.0, and 2.0 mg/kg) can effectively reduce the symptoms of acute gouty arthritis, and the effect is dose-dependent

The cell number was also normalized

Changes in body composition typically become apparent after 3-6 months of consistent therapy

Therefore, PCR amplification products were sent for gene sequencing, and comparison with wild-type sequences confirmed the successful deletion of the target bases in GSTM1 and GSTT1 ( Figure 4B )

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