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ZhongZZhangYWeiYLiXRenLLiYet alFucoidan improves early stage diabetic nephropathy via the gut microbiota-mitochondria axis in high-fat diet-induced diabetic mice

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Discussion We demonstrated in the first part of the present work that both glutathione trisulfide (GSSSG) and lipoic acid trisulfide (LASSS) have potent redox characteristics that prevent nitration of Y198 and Y250 of the HGF -chain, thereby preserving the ability of HGF to bind to the receptor c-met and hence activate myogenic stem satellite cells in vitro (Figure 1b-d, and Figure 1e left column)

Vet Pathol 58(5), 923-934

It is composed of 44 amino acids and a trans-3-hexenoic acid group, which makes it more stable and extends its half-life as compared to endogenous GHRH