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To date, several microRNAs are known to upregulate P-gp expression (including miR-138 and miR-296), while others downregulate P-gp expression (including miR-1253 and miR-298) [82]

Buse added that some data suggest adding cagrilintide could allow a lower dose of semaglutide with fewer unpleasant gastrointestinal side effects without sacrificing the benefits of glycemic management and weight loss

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