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Hesperetin also may inhibit histone H3K79 methylation by the degradation Disruptor of telomeric silencing 1 (Dot1) expression through CBP-mediated acetylation and, consequently, a reduction in cell migration and invasion in gastric, breast, lung, liver, and colon cancer (74)

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Appl Environ Microbiol 81:25062514

These inhibitors work by restricting enzyme movement, either by forming ring barriers around the enzyme or by wedging between the enzymes subunits

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