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IJPR 12 (1), 123129

McFadden and colleagues also reported improvements in quality of life and pulmonary function tests (PFTs) and a reduction in systemic and topical corticosteroid requirements[83]

Low-level local ROS are significant because they regulate critical transcription factors (NFB/IB, Nrf2/KEAP1, AP-1, p53, HIF-1) and act as redox-signaling molecules in a variety of pathways involved in ensuring the maintenance of cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR)

doi: 10.1111/j.1600-079X.1998.tb00361.x, [DOI] [PubMed] [Google Scholar] 164.Perez-Gonzalez A, Castaneda-Arriaga R, Alvarez-Idaboy JR, Reiter RJ, Galano A