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These proteinmetabolite interaction networks were as follows IL6bilirubin interaction (having a high confidence score of 0.934 or 93.4% including the database and text mining-based scores), GPX3butyric acid (butyrate) interaction (having a high confidence score of 0.853 or 85.3% including text mining-based scores), LEPbutyric acid (butyrate) interaction (having a high confidence score of 0.842 or 85.3% including text mining-based scores), GSTM2butyric acid (butyrate) interaction (having a high confidence score of 0.824 or 82.4% including database and text mining-based scores), TNFbilirubin interaction (having a high confidence score of 0.752 or 75.2% including text mining-based scores), ACADMoctanoylcarnitine (octanoylcarnit.) interaction (having a high confidence score of 0.75 or 75% including text mining-based scores) (Figure 1

& Stanton, C

& Thamarangsi, T

However, treatment with DAPA significantly upregulated Nrf2 and HO-1 expression

RNA splicing of the BHC80 gene contributes to neuroendocrine prostate cancer progression