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Identification of novel human nicotinamide N-methyltransferase inhibitors: a structure-based pharmacophore modeling and molecular dynamics approach

Greenwood, H

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however, intrinsic resistance to ferroptosis limits its therapeutic efficacy

Parkin modulates activity of redox state-sensitive, mitochondrial enzymes To link our redox chemistry findings back to the identified changes from proteomic screens conducted in parkin-deficient mouse brain [36, 38], we explored the activities of select, redox-sensitive enzymes