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The authors reported that cagrilintide adopts an amylin-like pose while inducing receptor-specific conformational dynamics, offering a structural framework for interpreting its pharmacology.

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In controlled sleep research, DSIP has been associated with increased sleep pressure and improvements in sleep parameters vs placebo

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Interestingly, several fragment hits originating from our second XChem screen possess alternative groups to the sulfonic acid that interact with R131 and R102, which opens up opportunities to link and merge hit matter found across the TIN2 leucine and phenylalanine binding pockets