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High oxygen concentrations can directly damage alveoli, particularly alveolar type II epithelial cells, which are critical to both alveolar development and repair (Nabhan et al., 2018

Heterocycle encompasses single ring or multiple condensed rings, including fused, bridged and spiro ring systems

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Campbell JA, Corrigall AV, Guy A, Kirsch RE (1991) Immunohistologic localization of alpha, Mu, and Pi class glutathione S-transferases in human tissues

Two Phase I, Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies of TAS-109, a novel nucleoside analogue with 14 days and 7 days continuous infusion (CI) schedules, 2008