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Specifically, a BAC between 0.30% and 0.40% results in loss of consciousness, and levels exceeding 0.40% significantly increase the risk of coma or death due to respiratory arrest

It is presumed to be due to alcohol's effect on the cerebellum

[32] There is also mounting evidence for consideration of SR as an endophenotype with some studies suggesting that it accounts for a significant proportion of genetic risk for the development of alcohol use disorder