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In addition, CNS-associated macrophages are also located between astrocyte terminals and parenchymal vessels, where they extend into the perivascular space and participate in immune processes by phagocytosing debris (32)

50,51 The normal range of bilirubin concentration in the blood is 6 mg/dL (102 uM), and at least 25 mg/dL (427 uM) in cases of severe hyperbilirubinemia

These findings are particularly compelling as they suggest that BPC 157 could be a game-changer in the field of medicine, providing solutions where conventional treatments often fall short

As previously described for pomalidomide, new derivatives can be synthesized from 5-aminothalidomide (49) by acylating the primary amine with acyl chloride linkers, or directly with a carboxylic acid terminal linker, leading to compound 50