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[257] The European Medicines Agency (EMA) followed suit on 28 May 2021

The anti-arthritic effect of Nano ZT/Vit B12 may be supported by the suppression of inflammation, the reduction in oxidative stress, the enhancement of the antioxidant defense system, the increase in anti-inflammatory markers such as TIMP-3 and IL-4, and the decrease in ADAMTS-5, TGF-, and MMP-13 levels (Figure 13)