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No Observed Effects On: Blood glucose or insulin sensitivity (no diabetogenic effects) IGF-1 levels (remained within normal ranges) Blood pressure or cardiovascular parameters Thyroid function Liver or kidney function markers Important: The absence of growth hormone-related side effects distinguishes AOD-9604 from full-length GH, which can cause fluid retention, joint pain, carpal tunnel syndrome, and insulin resistance

Safety and Pharmacology Evaluations : Conducting preclinical toxicology, pharmacokinetic, and receptor-binding studies to characterize how AOD 9604 is handled in vivo and confirm it does not activate growth hormone-like proliferative pathways

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Activity was monitored via quantification of radiolabeled reaction product histone [methyl- 3 H]-L-arginine