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Description

This might not be the only redox switch for this protein since four other cysteine residues are well conserved in APKs from terrestrial plants

Homocysteine as a risk factor for vascular disease

doi: 10.4049/jimmunol.1202215 144 YangS

Under normal physiological conditions, NRF2 is extremely unstable, can be ubiquitinated by Kelch-like ECH-associated protein 1 (KEAP1), and is rapidly degraded by the proteasome pathway