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This leads to inflammatory responses and heightened intestinal permeability, thus compromising the intestinal barrier [47, 48]

Importantly intracellular glutamate is a precursor of glutathione synthesis and, accordingly, HIF1-dependent intracellular glutamate accumulation can be used for glutathione biosynthesis, which can ultimately promote cell survival by counteracting oxidative stress (Stegen et al., 2016)

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They are formed in mitochondria as oxygen is reduced along the electron transport chain

still in an attempt to make and study a more co-operative polyQ in touch neurons, we constructed a single copy bzSi39 [P mec-7 mNG::HttQ74] allele