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[1] [11] Reevaluation at three- to six-month intervals allows clinicians to ascertain whether the dose can be reduced or the injection interval extended, reflecting current endocrine guidelines that emphasize the lowest effective estrogen exposure and periodic attempts at cessation once symptoms abate

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"Beta-3 Adrenergic Receptor Agonism as a Mechanism for Inducing Lipolysis in Human Adipocytes." Adipocyte Biology & Metabolism, 23(2), 40-47