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Today it is available only by prescription, compounded by state-licensed 503A pharmacies or FDA-registered 503B outsourcing facilities, neither of which is independently reviewed or approved by the FDA as a finished drug product, most commonly prescribed off-label for adult GH decline or wellness/anti-aging use

doi: 10.1111/cei.12631 20 BulatV.SitumM.AzdajicM

451,453 AGE/RAGE on mononuclear macrophages increases CD36 expression, promotes OX-LDL uptake while decreasing high-density lipoprotein (HDL) efflux, and promotes foam cell formation

Mechanick JI, Apovian C, Brethauer S, et al