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11F) and MDA (Fig

Both doses of alpha-lipoic acid moderately decreased self-reported pain compared to baseline, with somewhat better results at the higher dose, while there was no decrease in pain with placebo

\n\n\n\n It is critical to note, however, that preclinical safety data no matter how consistently positive cannot be directly extrapolated to humans without proper clinical trials

The observed differences appear to be dependent on the animal model, as previous studies have shown that MitoQ is well tolerated at concentrations up to 500 M in drinking water over several weeks, without causing adverse effects on behavior or metabolism (57, 83)

MK-677 has a 24-hour half-life, requiring daily oral administration to sustain continuous ghrelin receptor agonism