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73,74 ATP7B, encodes a P-type adenosine triphosphatase metal ion transporter that is mainly expressed in hepatocytes

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Pharmacologic activation of this pathway by metformin amplifies Treg populations (90, 104), while glycolysis inhibition with 2-deoxyglucose (2-DG) shifts metabolism toward FAO, thereby promoting a phenotypic switch from Th17 to Treg cells (82)