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Severe deficiency can contribute to fatty liver changes, which is one reason choline gets framed as liver support. Details are summarized in the NIH ODS Choline fact sheet for health professionals

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The B12 wont become toxic, but it will gradually lose potency

Additionally, even though Nrf2 activation was seen in vivo , aldosterone-treated rat kidneys showed significant DNA damage, showing that the response was insufficient to shield the animals from these side effects (75)

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