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A significant finding was the dysregulation of purine metabolism, a pathway that plays dual roles in maintaining intracellular energy homeostasis and mediating extracellular purinergic signaling

Mol Pharm 11(3):653664

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In a recent study, researchers performed RNA-seq and ChIP-seq on tissue samples from AH livers and normal livers and found that several CXCL chemokines, including CXCL1, CXCL6, and CXCL8, which are involved in neutrophil recruitment, showed significantly increased expression in the livers of AH patients