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The two water molecules within the active site with 43 were able to help bridge new interactions that account for the improved inhibitory activity compared to the other inhibitors

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World J Gastroenterol 25(21):25392548 Nishii R, Moriyama T, Janke LJ, Yang W, Suiter CC, Lin TN et al (2018) Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy