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Contraindications include known hypersensitivity to glutathione or sulfur-containing compounds, pregnancy and lactation (insufficient safety data), and severe renal impairment (impaired clearance may cause accumulation)

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J Dermatol Sci 81:107117 Ggotek A, Domingues P, Skrzydlewska E (2018) Proteins involved in the antioxidant and inflammatory response in rutin-treated human skin fibroblasts exposed to UVA or UVB irradiation