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On the other hand, other authors have shown that MPP + induces negative effects in astrocytes, such as loss of viability, impairment of energetic metabolism of mitochondria, ROS generation and decrease in the glutamate clearance by astrocytes [81,85,86]

The findings suggested that the integrity of the intestinal barrier was compromised in the animal models of diabetes, as evidenced by a reduction in the expression of adhesion proteins in the intestines