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Together with this lagging strand-associated pathway, other key replisome components in leading or lagging strand such as PCNA and its loader RFC-Ctf18, MCM, Ctf4 cooperate for efficient Sororin recruitment through SMC3 acetylation

Therapeutic interventions have been developed and are used clinically, directly targeting epigenetic processes including DNA methylation (e.g., Decitabine) or histone modifications (e.g., Vorinostat), and gene therapies that mimic or counter the effects of ncRNAs are in development