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However, for medicines with a narrow therapeutic index (where small changes in blood levels can affect safety or efficacy), more careful monitoring may be needed

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As with a high protein intake, the only issue may occur in individuals with kidney or liver disease [18][19]

It is also worth noting that animal model studies have illustrated a mechanistic contribution of microbial TMA and TMAO generation to enhanced development of atherosclerosis, platelet reactivity and thrombosis, and both impairment in renal function and fibrosis, as well as adverse ventricular remodeling and heart failure (refs

Initial perfusion and 30 hours ice storage