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The first big increase occurred in May 1994, when Proposal A, a ballot initiative, tripled the state's cigarette tax to 75 cents per pack, then the highest in the nation.[30] Michigan then increased its cigarette excise tax rate to $1.25 per pack in August 2002 and to $2.00 in July 2004, an increase of 167 percent in less than two years

How Smoking Affects the Liver Increased Oxidative Stress and Inflammation: Oxidative Stress: Smoking introduces a host of toxic chemicals into the body, which increases oxidative stress