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After 2 weeks of usual treatment with a 21-mg patch, participants who fail to quit smoking (target n = 400) will be randomized to receive escalating doses of a nicotine patch vs matching placebo patches for an additional 10 weeks or up to a maximum dose of 84 mg per day

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Patients can also be encouraged to inform family members about this possibility so they can be alert to any concerning changes

In 2018, 4.3% of high school students who used e-cigarettes reported buying the products from an online retailer