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After a hiatus of 23 years, Hotchkiss has described DNA methylation in calf thymus DNA in 1948 [18, 19]

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FIGURE 2 Extensive research suggests that neuroprotective plant extracts exert their effects in PD animal models through multi-target mechanisms, including the inhibition of abnormal -syn aggregation, promotion of its clearance, and alleviation of neuroinflammation and oxidative stress