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Costa and colleagues demonstrated that the administration of tin protoporphyrin IX (SnPPIX), an HO-1 enzymatic inhibitor, decreases pulmonary Mtb loads comparable to that accomplished by anti-TB drug therapy as well as improves the bactericidal activity of anti-TB drugs (RIF, INH, and PZA) (192)

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It was diluted with the same KCl, EDTA, Tris solution containing 0.75 g NaCl/100 ml to produce solutions of 18.4% and 13.8% Nycodenz ( = 1.098 and 1.075 respectively)

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