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This remarkable selectivity is driven by the highly negative membrane potential of healthy mitochondria, which electrostatically attracts the positively charged SS-31 molecule

Natural compounds like midazolam, vitamin B12, metformin, Cangrelor, and hesperidin have also shown anti-inflammatory effects in preclinical MIRI models, often by modulating macrophage polarization or inhibiting inflammatory pathways like NF-B (Huang et al., 2020

Vectors derived from RV, alphaviruses, and ADV have also been utilized to combat human diseases

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