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However, excess copper directly binds to GSH, causing its rapid consumption (103) and significantly diminishing the cellular antioxidant reserves

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Curr Rev Musculoskelet Med 12(2):105116

The geometric LS mean ratios of the AUC inf were 1.53, 2.30, and 3.69 in the mild renal impairment, moderate renal impairment, and severe renal impairment groups, respectively, versus matched normal renal function groups