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The GM is composed not only of bacteria but also fungi, viruses, protists, and archaebacteria, the latter thriving in extreme anaerobic environments through metabolic processes such as methanogenesis [48,49]

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Therefore, there is an urgent need for alternative therapeutic approaches, including plant-derived phytochemicals, that can directly modulate the core pathogenic mechanisms of PD, such as neuroinflammation, mitochondrial dysfunction and S aggregation

Interestingly, the same results were not observed in healthy age-matched mice, as 6 weeks of progressive ladder-climbing RT (3 climbs, progression from 50% to 100%MCL, 5 times per week) decreased lipid peroxidation in the cerebral cortex but increased lipid peroxidation in the hippocampus (Schimidt et al., 2019)

For patients with melasma or deeper skin tones, mandelic acid and low-concentration glycolic peels are preferred over aggressive protocols to minimize post-inflammatory risk