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As MTX is chiefly excreted by the kidneys, MTX-mediated renal injury leads to delayed clearance of MTX, causing persistent elevation of plasma MTX level, leading to ineffectual rescue by leucovorin and obvious augmentation of MTXs related toxicities [12]

4i and Extended Data Fig

Effect of oral calcium disodium EDTA on iron absorption in a human model of iron overdose

Results vary significantly between individuals

5 Therapeutic implications of gut microbiota modulation Modulating the gut microbiota presents a novel therapeutic approach for urolithiasis prevention and treatment