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Supporting this, Bahr et al

Conclusion An emerging and promising approach in SCD management involves harnessing endogenous clearance mechanisms for hemolysis products

Originally described by Christian de Duve in 1963 as a process involving lysosomes and their enzymes to degrade cellular components, autophagy is now understood to be as far more complex event that is intricately regulated by genetics, pathology, and other factors (Levine and Kroemer, 2008