Pulmonary artery pressure (Ppa), tracheal pressure (Pt), and the rate of lung weight gain (LWG) were measured continuously
The overlap with Hypermobility syndrome, Chronic Fatigue and Autonomic Dysfunction with Orthostatic Intolerance or Parasympathetic Excess states leads us to believe that there is mechanism at the cellular level, which causes an acquired Mitochondria Dysfunction with abnormal energetics producing energy from the body, and that the insulting agents that trigger this are in may cases infectious or inflammatory and can be worsened by emotional stress or trauma stress
List of Abbreviations ACL anterior cruciate ligament AGE advanced glycation end product AP-1 activating protein-1 BAPN -aminopropionitrile BMP-1 bone morphogenetic protein-1 Col1a1 collagen type I alpha 1 chain Col3a1 collagen type III alpha 1 chain CRL cytokine receptor-like CSA cross-sectional area CypB cyclophilin B DOGDIC 3-deoxyglucosone-derived imidazolium ECM extracellular matrix ER endoplasmic reticulum GODIC glyoxal-derived imidazolium HH Hamburger-Hamilton HIF hypoxia inducible factor HP hydroxylysyl pyridinoline hPDL human periodontal ligament HPLC high-performance liquid chromatography Hyl hydroxylysine JNK c-Jun N-terminal kinases LH lysyl hydroxylase LOX lysyl oxidase LOXL LOX-like protein LOX-PP LOX pro-peptide LP lysyl pyridinoline LTQ lysyltyrosine quinone MAPK mitogen-activated protein kinase MCL medial collateral ligament MCP 2-mercaptopyridine-N-oxide MGO metabolite methylglyoxal MMP matrix metalloproteinase MODIC methylglyoxal-derived imidazolium P3H prolyl-3-hydroxylase P4HA prolyl 4-hydroxylase subunit alpha PCP procollagen-C-proteinase PDI protein disulfide isomerase PDL periodontal ligament PIEZO1 Piezo type mechanosensitive ion channel component 1 PLOD procollagen lysyl hydroxylase Pyr pyridinoline RT-PCR reverse transcription polymerase chain reaction SAXS small-angle X-ray scattering SDFT superficial digital flexor tendon SDS-PAGE sodium dodecyl sulfatepolyacrylamide gel electrophoresis SEM scanning electron microscopy SLRP small leucine-rich proteoglycan SNAIL snail SOX9 SRY-box transcription factor 9 TCP trans-2-phenylcylopropylamine TEM transmission electron microscopy TG transglutaminase TGF transforming growth factor beta TGFR TGF receptor Thbs1 thrombospondin-1 gene TIMP tissue inhibitor of MMP TSP-1 thrombospondin-1 References Ahmed AS, Schizas NL,J, Ahmed M, Ostenson C-G, Salo P, Hewitt C, Hart DA, Ackermann PW (2012) Type 2 diabetes impairs tendon repair after injury in a rat model
In e data is represented as boxplot where the middle line is the median, the lower and upper hinges correspond to the first and third quartiles, the upper and lower whisker extends from the hinge to the largest and smallest value respectively no further than 1.5 IQR from the hinge (where IQR is the inter-quartile range)
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