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Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) studies have shown widespread reductions in cerebral metabolism, while functional Magnetic Resonance Imaging (fMRI) studies have revealed more pronounced alterations in functional brain networks in TLE patients with depression (Struck et al., 2021)

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**BPC-157, a synthetic gastric pentadecapeptide studied primarily in animal models for tissue repair, gut healing, and anti-inflammatory effects, remains unapproved by the FDA as a finished drug with only limited small-scale human data available.** It was placed in Category 2 in 2023 due to concerns over immunogenicity, peptide impurities, and insufficient safety information for compounding under Section 503A